While on a dermatology elective at Henry Ford Hospital in Detroit, Dr. Greenberg worked with Dr.'s David Fivenson & Tor Schwayder on an article regarding the use of Lotrisone (betamethasone/clotrimazole) in pediatric patients. Lotrisone is a combination product that many physicians use to treat disorders of the skin when the diagnosis is in question. The major problems with Lotrisone are identified within the article- but are related to the high potency steroid component of the product: striae, thinning of the skin and blood vessels being brought to the surface were all seen as complications from long term drug use. The article suggests that Lotrisone should not be used in children, especially for extended periods of time because of the side effect profile.

Greenberg, H.L., Shwayder, T.A., Biezck, N., Fivenson, D.: Clotrimazole/ Betamethasone Diproprionate: A Review of Costs and Complications in the Treatment of Common Cutaneous Fungal Infections. Pediatric Dermatology Volume 19 (1), p.78-81, January/February 2002.